The major goal of our research is to understand how molecular and force generating mechanisms drive cell movement. Specifically, we are interested in how force-sensing mechanisms organize cytoskeletal function to produce movement.
To study the interrelationship between molecular dynamics and force generation we use a combination of live-cell fluorescence imaging with cell biological and biophysical techniques.
We typically study fast moving cell types such as fish epithelial cells, Dictyostelium amoebae and leukocytes, due to their relevance to the increased motility associated with metastatic cancer.
Lee Lab 2013
